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In the group assigned to receive 30 mg of aspirin,the frequency of death from vascular causes,nonfatal stroke,or nonfatal myocardial infarction was 228 of 1555(14.7percent),as compared with 240 of 1576(15.2percent)in the group assigned to receive 283 mg.The age-and sex-adjusted hazard ratio for the group receiving the lower dose was 0.91(95 percent confidence interval,0.76 to 1.09).There were slightly fewer major bleeding complications in the 30-mg group than in the 283-mg group(40 vs 53),and significantly fewer reports of minor bleeding(49 vs 84).Fewer patients receiving 30 mg of aspirin reported gastrointestinal symptoms(164 vs 179) and other adverse effects(73 vs 90).Our date indicate that 30 mg of aspirin daily is no less effective in the prevention of vascular events than a 283-mg dose in patients with a transient ischemic attack or minor stroke,and has fewer adverse effects. |
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